Current Openings

We are seeking an exceptional individual to lead Bioanalysis and Drug Metabolism and Pharmacokinetics (DMPK) at Blend Therapeutics. The successful candidate will develop our understanding of our proprietary molecules and nanoparticles in vitro, in preclinical species, and ultimately in humans through very highly collaborative interactions with relevant scientists from other key functions. The successful candidate will contribute to our knowledge of the disposition of our unique molecules and formulations, further develop our bioanalytical capabilities and continue to expand our skills to evaluate pathways important in the disposition of nanoparticle encapsulated drugs

Primary responsibilities of the position will include:

  • Lead the DMPK group at Blend with a focus on bioanalysis including routine plasma pharmacokinetics as well as tissue analyses.
  • Establish a state of the art model for evaluating disposition of proprietary drugs and nanoparticles, including the analytical tools to follow metabolism and distribution 
  • Support regular rodent pharmacokinetic studies including fast bioanalysis and compartmental modeling to support the team with needed data.
  • Develop in vitro techniques to use as screens to predict the in vivo behavior of proprietary drugs
  • Interface with safety assessment experts to characterize the full pharmaco- and toxicodynamic properties of Blend’s novel class of agents 
  • Interface with clinical operations, clinical pharmacology, consultants, and other interdisciplinary teams to support Blend’s clinical programs.
  • Supervise 1-2 full time employees to achieve Project and Product development goals.
  • Be a role model for leadership across the organization, by effectively communicating a vision for the success of our projects.
  • Effectively identify and managing external vendors to provide high-quality deliverables within established timelines and budgets.
  • Ensure operational excellence by applying high industry standards, policies, systems, and processes.
  • Document, organize and interpret data, and present results to stakeholders at multiple levels.
  • Write and review documents for internal processes and external interactions.
  • Maintain and build value through capturing know-how and intellectual property.
  • Ensure compliance with company policies and procedures, as well as other applicable rules, guidelines and codes of practice required by regulators or law.

The successful candidate will have the following credentials:

  • A PhD in a pharmacokinetics, pharmacology, chemistry, biochemistry or related field with 5-10 or more years spent overseeing all key aspects of the DMPK activities in pharmaceutical development.
  • Significant experience in the analysis of biological fluids and tissues for drug exposures including knowledge of Mass Spectrometry.
  • Knowledge of pharmacokinetics and use of WinNonLin or related systems required for the analysis of PK data from preclinical species and humans.
  • Also interface with current and future partners in a highly professional and effective manner.
  • Exceptional communication capabilities and team building experience with a record of proven collaborative success is mandatory.
  • Significant contributions to the success of novel pharmaceutical agents with direct experience authoring appropriate sections of regulatory documents supporting applications for human dosing and experience interacting with partners.
  • Experience and success establishing capabilities (both internal and external) for the specific task of evaluating drug disposition including in vitro assays evaluating the role of CYP isozymes and drug transporters in clearance as well as the establishment of hepatocyte cultures for the evaluation of metabolism.
  • Prepare appropriate sections of regulatory and other documents to support filing of applications for human dosing including IND’s, CTA’s, and represent the company at Agency meetings as needed.

Required Competencies

  • Leadership
  • Teamwork
  • Effective communication (written and oral)
  • Detail orientation
  • Independence
  • Results orientation
  • Multi-tasking
  • A strong sense of urgency

Please send your resume and a brief cover letter describing why you should be considered for the Director of Bioanalytical Chemistry and DMPK position to: Email: careers@blendtx.com

Blend Therapeutics Inc., 134 Coolidge Avenue, Watertown, MA 02472
Website: www.blendtx.com

Blend Therapeutics does not accept non-solicited resumes or candidate submittals from search/recruiting agencies not already on Blend Therapeutics’ approved agency list.

Blend Therapeutics is an Equal Opportunity Employer

Blend Therapeutics is a biopharmaceutical company discovering new classes of medicines to treat debilitating diseases. We are pioneering an integrative way to discover molecular entities with new mechanisms of action purposely designed for our proprietary nanoparticles. By synergistically developing new molecules and the most efficient drug delivery mechanisms together we can make medicines more targeted, effective and tolerable.

Our initial focus is on cancer therapies that uniquely target tumors with improved potency and reduced toxicity. Blend Therapeutics has built impressive capabilities in developing new chemical entities and drug delivery approaches towards achieving the goal of targeted therapies.
Our product development team is looking to expand our internal capabilities in formulation design and development. We seek candidates from diverse backgrounds who are passionate about developing integrated, mechanistically engineered nanomedicines that will result in important drugs for the treatment of cancer. The ideal candidate would be a part of a group that interfaces materials science, formulation design and characterization, and process development for the manufacture of novel drug products, from preclinical research through clinical development.

Position Qualifications:

  • BS, MS, or PhD in Pharmaceutical Sciences, Chemical Engineering, Materials Science, or related a field with 5+ (BS) or 1+ (MS) or 0-3 (PhD) years of relevant industry experience.
  • Knowledge of nanotechnology and understanding of nanoparticle formulation process including emulsions, filtration and purification is desirable
  • Additional experience working with polymers, peptides, and injectable drug formulations is desired.
  • Expertise in DSC, TGA, GPC, and characterization of nanoparticle properties such as particle size, zeta potential, drug loading and release is desired.
  • Demonstrated ability to analyze, verify and interpret laboratory data.
  • Ability to work in cross-functional teams.
  • Excellent oral, written, and interpersonal communication skills

Successful candidates will have the following credentials:

  • Basic knowledge and understanding of pharmaceutical formulation and pre-formulation processes.
  • Enthusiasm to learn and implement new laboratory processes and methods.
  • Strong interpersonal skills with the desire to contribute towards team success.
  • Excellent planning, organization and communication skills.
  • Demonstrate effective time management and attention to detail.
  • Ability to work in a fast paced environment and change gears quickly.

The above description is intended to describe the general nature of the job.  It is not an exhaustive list of all duties, and other duties may be assigned.

Please send your resume and a brief cover letter describing why you should be considered for the Senior Research Associate/Scientist I position to: Email: careers@blendtx.com

Blend Therapeutics Inc., 134 Coolidge Avenue, Watertown, MA 02472
Website: www.blendtx.com

Blend Therapeutics does not accept non-solicited resumes or candidate submittals from search/recruiting agencies not already on Blend Therapeutics’ approved agency list.

Blend Therapeutics is an Equal Opportunity Employer