Current Openings

Blend Therapeutics is a biopharmaceutical company discovering new classes of medicines to treat cancer. We are pioneering an integrative way to discover molecular entities with new mechanisms of action purposely designed for our proprietary nanoparticles. By synergistically developing both the molecule and the nanoparticle together we can make medicines more targeted, more effective and more tolerable. Reporting to a senior Scientist in the biology group, the incumbent will support in vitro biology by carrying out cell based assays to support lead candidate selection, mechanism of action studies, biomarker identification, as well as resistance mechanisms across multiple programs.

Responsibilities

  • Contribute to assay development as needed to support Blend programs
  • Perform cell based assays such as cell proliferation, cell signaling and downstream assays such as ELISA and Western Blotting
  • Stay current on relevant scientific literature
  • Contribute scientifically to project direction
  • Communicate and present findings internally to project teams
  • Work closely with cross-functional team members

Education & Requirements
B.S. in cell or molecular biology, biochemistry, or a related field required.  A minimum of 1 year experience in drug discovery in biotech or pharmaceutical settings but ideally five years’ experience.  Functional knowledge of cell based assays and assay development. Candidate has a proven ability to work independently with excellent teamwork, organizational and communication skills.  Previous experience in immunofluorescence and high content screening imaging modalities is a plus but not necessary.  Oncology experience is highly preferable but not required. 

Blend Therapeutics, Inc. is a vibrant, entrepreneurial EEO employer committed to a diverse and dynamic workplace. Blend offers a competitive benefits package.

Blend Therapeutics is seeking high-energy, talented people who want to work in a collaborative team environment to discover and develop innovative new medicines that will make a meaningful difference for patients.

Blend Therapeutics is a biopharmaceutical company discovering new classes of medicines to treat debilitating diseases. We are pioneering an integrative way to discover molecular entities with new mechanisms of action purposely designed for our proprietary nanoparticles. By synergistically developing both the molecule and the nanoparticle together we can make medicines more targeted, effective and tolerable.

Position Summary:
The Director of Clinical Operations will manage all aspects of clinical and data operations including the oversight of study management, clinical monitoring, adverse event reporting, ongoing safety review, protocol design, protocol adherence and ICH/GCP compliance. The Director of Clinical Operations will also be responsible for the development and management of timelines and budgets related to clinical trials in collaboration with management and cross-functional teams.

Summary of responsibilities:

  • Assure high quality and timely execution of clinical trials from protocol development through clinical study report in conjunction with appropriate internal departments and external collaborators.
  • Assure integration and coordination of clinical trial management, clinical trial monitoring, clinical data management and data analysis functions for the timely completion of high quality publications (i.e. posters, abstracts, study reports) and submissions.
  • Ensures that operational performance is in alignment with company strategies and goals.
  • Responsible for the design and communication of departmental strategy (e.g. vendor selection and management strategies, departmental structure and growth).
  • Interface with senior management regarding trial conduct and related activities.
  • Oversight of development and training of new SOPs and updating current SOPs pertaining to managing clinical trials.
  • Manage clinical trial budgets and timelines in conjunction with Finance.
  • Oversight of all vendors related to the execution of clinical trials
  • Responsible for resource planning for the Clinical Operations department.
  • Assist in the clinical evaluation of new business opportunities.

Position Qualifications:

  • Clinical Operations experience in a biotech or pharmaceutical/CRO/ARO organization with demonstrated proficiency managing clinical programs and teams.
  • Experience in execution of oncology clinical trials preferred, including experience in both small Phase 1studies and larger, multi-center trial management.
  • Extensive knowledge of FDA regulations and ICH guidelines regarding GCPs.
  • Experience selecting and managing CROs.

Minimum requirements:
8 years experience in clinical research.  A BS/BA degree in life sciences required, with an advanced degree preferred.

 

Blend Therapeutics is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law.

Please submit your resume to careers@blendtx.com

Blend Therapeutics, Inc., 134 Coolidge Ave., Watertown, MA 02472
www.blendtx.com

Blend Therapeutics is seeking high-energy, talented people who want to work in a collaborative team environment to discover and develop innovative new medicines that will make a meaningful difference for patients.

Blend Therapeutics is a biopharmaceutical company discovering new classes of medicines to treat debilitating diseases. We are pioneering an integrative way to discover molecular entities with new mechanisms of action purposely designed for our proprietary nanoparticles. By synergistically developing both the molecule and the nanoparticle together we can make medicines more targeted, effective and tolerable.

Position Summary:
Working at the interface of formulation and analytical development to provide analytical tools and support chemistry, process and formulation development at Blend.

Responsibilities include:  

  • Assay development and sample analysis using analytical techniques like HPLC and LC/MS
  • Development and characterization of nanoparticle formulations for lead compounds.
  • Designing and conducting laboratory experiments
  • Executing various analytical techniques/tests and interpreting experimental results conducted toward physicochemical characterization of drug product
  • Maintaining accurate records of experiments and making well structured, data driven decisions
  • Communicating results effectively.

Position Qualifications:
Degree in chemistry, analytical chemistry, pharmaceutical science, biochemistry, or related scientific discipline with related laboratory experience, including design and execution of related experiments, as noted below:

BS with 6+, MS with 3+ or PhD with 0-2 years of experience.

Minimum requirements:

  • Demonstrated knowledge and understanding of analytical methods development for small molecules and peptides.
  • Knowledge of nanotechnology and understanding of nanoparticle formulation process including emulsions, filtration and purification.
  • Additional experience working with polymers, peptides, and lipids formulations.
  • Expertise in DSC, TGA, GPC, and characterization of nanoparticle properties such as particle size, zeta potential, drug loading and release is desired.
  • Demonstrated ability to analyze, verify and manipulate laboratory data.
  • Ability to work in cross-functional teams.
  • Excellent oral, written, and interpersonal communication skills.

Blend Therapeutics is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law.

Please send your resume and a brief cover letter describing why you should be considered for the Scientist I position to:  Beata Sweryda-Krawiec, Senior Scientist, bkrawiec@blendtx.com

Blend Therapeutics, Inc., 134 Coolidge Ave., Watertown, MA 02472
Website: www.blendtx.com

Formulation Development

Blend Therapeutics is seeking a student for a summer internship in Formulation Development at its Watertown, MA facility. As a Formulation Development intern, you will experience the role of a full-time R&D scientist and participate on our innovative projects teams. Our internship program provides you with the opportunity to experience the environment of a small biotech company and gain experience across multiple functional areas at the forefront of drug development. You will have the opportunity to work on formulations for novel chemical entities, primarily focused on designing and characterizing novel drug nanoparticles, developing skills in formulation, analytics, nanoparticle design and characterization.

Eligibility requirements:

  • Candidates must be working towards the completion of a Bachelor’s or Master’s degree in a Science or Engineering discipline. Degrees focused in Chemistry, Pharmaceutical Science, Materials Science, Engineering, and related subjects are preferred.

Successful candidates will have the following credentials:

  • Some knowledge and/or interest with polymeric materials and novel drug delivery technologies (e.g. nanoparticles) are desired.
  • Enthusiasm to learn and implement new laboratory processes and methods
  • Strong interpersonal skills with the desire to contribute towards team success
  • Excellent planning, organization and communication skills.
  • Demonstrate effective time management and attention to detail.
  • Ability to work in a fast paced environment and change gears quickly.

Please send your resume and a brief cover letter describing why you should be considered for this internship position to; Patrick Lim Soo, Senior Scientist, plimsoo@blendtx.com

Blend Therapeutics, Inc., 134 Coolidge Ave., Watertown, MA
Website: www.blendtx.com