Current Openings

Blend Therapeutics is an oncology focused biopharmaceutical company discovering new classes of medicines. We are pioneering an integrative way to discover molecular entities with new mechanisms of action purposely designed for our delivery platforms. We are seeking high-energy, talented people who want to work in a collaborative team environment to discover and develop innovative new medicines that will make a meaningful difference for patients.

We are seeking an exceptional individual to hire as a Research Associate in Bioanalysis and Drug Metabolism and Pharmacokinetics (DMPK) at Blend Therapeutics. The successful candidate will develop our understanding of our proprietary molecules and delivery approaches in vitro and in preclinical species through very highly collaborative interactions with relevant scientists from other key functions. The successful candidate will contribute to our knowledge of the disposition of our unique molecules and formulations and further develop and our bioanalytical and DMPK capabilities.

Position Summary:
Bioanalytical and DMPK group member supporting pharmacokinetic and drug metabolism studies in drug discovery and development.

Responsibilities include: 

  • Develop and perform methods for extraction of small molecules from various biological matrices (e.g., plasma and tissue)
  • Develop and conduct LC/MS/MS assays for quantitation of small molecules from various biologic matrices
  • Complete bioanalytical assay qualifications per regulatory guidelines in support of discovery and development programs
  • Designing and conducting laboratory experiments
  • Maintaining accurate records of experiments and making well structured, data driven decisions
  • Communicating results effectively.

Position Qualifications:
Degree in chemistry, analytical chemistry, pharmaceutical science, biochemistry, or related scientific discipline with related laboratory experience, including design and execution of related experiments, as noted below:

BS with 2+, MS with 0-5 years of experience.

Minimum requirements:

  • Demonstrated knowledge and understanding of bioanalytical methods development for small molecules and peptides.
  • Experience performing bioanalysis using LC/MS/MS
  • ADME/DMPK knowledge is a plus
  • Demonstrated ability to analyze, verify and interpret laboratory data.
  • Ability to work in cross-functional teams.
  • Excellent oral, written, and interpersonal communication skills.

Required Competencies:

  • Teamwork
  • Effective communication (written and oral)
  • Detail orientation
  • Independence
  • Results orientation
  • Multi-tasking
  • A strong sense of urgency

Blend Therapeutics is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law.

Please send your resume and a brief cover letter describing why you should be considered for the position to: 

Mark Bilodeau, Ph.D.
Senior VP Chemistry
Blend Therapeutics, Inc.
134 Coolidge Ave.
Watertown, MA 02472

Blend Therapeutics does not accept non-solicited resumes or candidate submittals from search/recruiting agencies not already on Blend Therapeutics’ approved agency list.

Blend Therapeutics is an Equal Opportunity Employer

We are seeking an exceptional individual to lead Bioanalysis and Drug Metabolism and Pharmacokinetics (DMPK) at Blend Therapeutics. The successful candidate will develop our understanding of our proprietary molecules and nanoparticles in vitro, in preclinical species, and ultimately in humans through very highly collaborative interactions with relevant scientists from other key functions. The successful candidate will contribute to our knowledge of the disposition of our unique molecules and formulations, further develop our bioanalytical capabilities and continue to expand our skills to evaluate pathways important in the disposition of nanoparticle encapsulated drugs

Primary responsibilities of the position will include:

  • Lead the DMPK group at Blend with a focus on bioanalysis including routine plasma pharmacokinetics as well as tissue analyses.
  • Establish a state of the art model for evaluating disposition of proprietary drugs and nanoparticles, including the analytical tools to follow metabolism and distribution 
  • Support regular rodent pharmacokinetic studies including fast bioanalysis and compartmental modeling to support the team with needed data.
  • Develop in vitro techniques to use as screens to predict the in vivo behavior of proprietary drugs
  • Interface with safety assessment experts to characterize the full pharmaco- and toxicodynamic properties of Blend’s novel class of agents 
  • Interface with clinical operations, clinical pharmacology, consultants, and other interdisciplinary teams to support Blend’s clinical programs.
  • Supervise 1-2 full time employees to achieve Project and Product development goals.
  • Be a role model for leadership across the organization, by effectively communicating a vision for the success of our projects.
  • Effectively identify and managing external vendors to provide high-quality deliverables within established timelines and budgets.
  • Ensure operational excellence by applying high industry standards, policies, systems, and processes.
  • Document, organize and interpret data, and present results to stakeholders at multiple levels.
  • Write and review documents for internal processes and external interactions.
  • Maintain and build value through capturing know-how and intellectual property.
  • Ensure compliance with company policies and procedures, as well as other applicable rules, guidelines and codes of practice required by regulators or law.

The successful candidate will have the following credentials:

  • A PhD in a pharmacokinetics, pharmacology, chemistry, biochemistry or related field with 5-10 or more years spent overseeing all key aspects of the DMPK activities in pharmaceutical development.
  • Significant experience in the analysis of biological fluids and tissues for drug exposures including knowledge of Mass Spectrometry.
  • Knowledge of pharmacokinetics and use of WinNonLin or related systems required for the analysis of PK data from preclinical species and humans.
  • Also interface with current and future partners in a highly professional and effective manner.
  • Exceptional communication capabilities and team building experience with a record of proven collaborative success is mandatory.
  • Significant contributions to the success of novel pharmaceutical agents with direct experience authoring appropriate sections of regulatory documents supporting applications for human dosing and experience interacting with partners.
  • Experience and success establishing capabilities (both internal and external) for the specific task of evaluating drug disposition including in vitro assays evaluating the role of CYP isozymes and drug transporters in clearance as well as the establishment of hepatocyte cultures for the evaluation of metabolism.
  • Prepare appropriate sections of regulatory and other documents to support filing of applications for human dosing including IND’s, CTA’s, and represent the company at Agency meetings as needed.

Required Competencies

  • Leadership
  • Teamwork
  • Effective communication (written and oral)
  • Detail orientation
  • Independence
  • Results orientation
  • Multi-tasking
  • A strong sense of urgency

Please send your resume and a brief cover letter describing why you should be considered for the Director of Bioanalytical Chemistry and DMPK position to: Email: careers@blendtx.com

Blend Therapeutics Inc., 134 Coolidge Avenue, Watertown, MA 02472
Website: www.blendtx.com

Blend Therapeutics does not accept non-solicited resumes or candidate submittals from search/recruiting agencies not already on Blend Therapeutics’ approved agency list.

Blend Therapeutics is an Equal Opportunity Employer