Drug Discovery

Discovering New Classes of Medicines

Blend’s approach for discovering and developing innovative medicines is built on two key capabilities: our new-molecule drug discovery engine and our patented nanotechnology engineering platform.

Our scientists bring together these two key capabilities in an integrative R&D process to design new molecules with novel mechanisms of action and to apply nanoparticle engineering that optimizes drug properties. This approach enables Blend to create new classes of drugs with superior efficacy and minimal off-target effects.

Our new-molecule drug discovery capabilities, initially focused on oncology, advance new molecules that target novel mechanisms and provide opportunities for differential anti-tumor efficacy, minimal effect on healthy tissue, and reduced potential for cancer-cell resistance. For example, the first two drugs in our pipeline demonstrate distinctive pharmacology, and our differentiated nanotechnology engineering platform enables us to enhance the therapeutic properties at the tumor site. 

Proprietary Assets

Our integrative drug discovery approach leverages the following proprietary technologies and capabilities:

New-Molecule Drug Discovery Engine
Blend’s initial focus is on discovering superior new molecules for oncology applications, including a new class of mono-functional platinum compounds and a new class of targeted drugs. Our team applies world-class expertise in mechanism-driven drug design and medicinal chemistry to optimize the properties of our drugs. Blend has a significant proprietary portfolio of new classes of platinum drugs as well as other novel therapies. 

Patented Nanoparticle Technology
Blend’s proprietary capabilities in nanoparticle engineering enable the optimization of the therapeutic properties of new molecules from the company’s portfolio. In particular, Blend’s nanoparticle engineering can be applied to yield high selectivity at the site of disease along with lower toxicity, using:

  • unique encapsulation chemistries for polymers and drugs across a broad range of physicochemical properties
  • self-assembling particle synthesis for generating therapeutic nanoparticles with optimal particle properties.